Semin Respir Crit Care Med 2021; 42(05): 706-716
DOI: 10.1055/s-0041-1733899
Review Article

Evidence for the Application of Sepsis Bundles in 2021

Erika P. Plata-Menchaca
1   Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
2   Department of Intensive Care, Hospital Clínic de Barcelona, Barcelona, Spain
,
Juan Carlos Ruiz-Rodríguez
1   Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
3   Department of Intensive Care, Vall d'Hebron Hospital Universitari, Vall d'Hebron, Barcelona, Spain
4   Department of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
,
Ricard Ferrer
1   Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
3   Department of Intensive Care, Vall d'Hebron Hospital Universitari, Vall d'Hebron, Barcelona, Spain
4   Department of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
› Author Affiliations
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Abstract

Sepsis represents a severe condition that predisposes patients to a high risk of death if its progression is not ended. As with other time-dependent conditions, the performance of determinant interventions has led to significant survival benefits and quality-of-care improvements in acute emergency care. Thus, the initial interventions in sepsis are a cornerstone for prognosis in most patients. Even though the evidence supporting the hour-1 bundle is perfectible, real-life application of thoughtful and organized sepsis care has improved survival and quality of care in settings promoting compliance to evidence-based treatments. Current evidence for implementing the Surviving Sepsis Campaign bundles for early sepsis management is moving forward to better approaches as more substantial evidence evolves.



Publication History

Article published online:
20 September 2021

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